Hydrochloric Acid
Sigma Aldrich Fine Chemicals Biosciences Hydrochloric acid ACS reag
HYDROCHLORIC Hydrochloric acid ACS reag
Aqua Solutions Hydrochloric Acid 0.1 Normal NIST Traceable
Hydrochloric Acid 0.1 Normal NIST Traceable
Medchemexpress LLC ARD-69 | 5MG
ARD-69 is a PROTAC degrader based on the E3 ubiquitin ligase VHL and targeting the androgen receptor which can induce androgen receptor (AR) protein degradation in AR-positive prostate cancer cells ARD-69 inhibits AR-regulated gene expression binds to the AR ligand binding domain at one end and binds to VHL at the other end prompting AR to be recruited to the E3 ubiquitin ligase complex triggering proteasome degradation thereby inhibiting AR signaling pathways and downstream gene expression (such as PSA TMPRSS2) ARD-69 can be used to study the treatment of castration-resistant prostate cancer (mCRPC)[1][2][3] br/ ARD-69 is composed of a target protein ligand (pink part) AR antagonist 14 (HY-172624) a PROTAC linker (black part) tert-Butyl 4-ethynyl-[1 4 -bipiperidine]-1 -carboxylate (HY-W442074) and a VHL-type E3 ubiquitinase ligand (blue part) VH 101 acid (HY-47070) among them the VHL ligand and the linker can form a conjugate VH 101-amide-piperidine-Pip-alkyn
Medchemexpress LLC ARD-69 50mg | 2316837-10-0 | 50 MG
ARD-69 is a PROTAC small-molecule degrader that targets the androgen receptor (AR) and is used in preclinical research to investigate AR signaling and castration-resistant prostate cancer. It recruits the VHL E3 ligase to promote ubiquitination and proteasomal degradation of AR, resulting in decreased AR-driven transcription and inhibited proliferation in AR-positive cell lines.
- Used for preclinical studies of AR degradation and prostate cancer models.
- Potent AR degrader with low-nanomolar cellular activity.
- High chemical purity suitable for biological assays.
- Soluble in DMSO at ≥ 200 mg/mL for in vitro formulation.
- Stable under recommended storage when protected from light.
Medchemexpress LLC ARD-69 1mg | 2316837-10-0 | 1 MG
ARD-69 is a PROTAC degrader based on the E3 ubiquitin ligase VHL and targeting the androgen receptor which can induce androgen receptor (AR) protein degradation in AR-positive prostate cancer cells ARD-69 inhibits AR-regulated gene expression binds to the AR ligand binding domain at one end and binds to VHL at the other end prompting AR to be recruited to the E3 ubiquitin ligase complex triggering proteasome degradation thereby inhibiting AR signaling pathways and downstream gene expression (such as PSA TMPRSS2) ARD-69 can be used to study the treatment of castration-resistant prostate cancer (mCRPC)[1][2][3] br/ ARD-69 is composed of a target protein ligand (pink part) AR antagonist 14 (HY-172624) a PROTAC linker (black part) tert-Butyl 4-ethynyl-[1 4 -bipiperidine]-1 -carboxylate (HY-W442074) and a VHL-type E3 ubiquitinase ligand (blue part) VH 101 acid (HY-47070) among them the VHL ligand and the linker can form a conjugate VH 101-amide-piperidine-Pip-alkyn
Pfaltz & Bauer Hydrochloric Acid 6M in Deio 1L | 7647-01-0
Hydrochloric Acid 6M in Deio 1L | 7647-01-0
Aqua Solutions Hydrochloric acid 4 N | 7647-01-0 | MFCD00011324 | 4 L
Hydrochloric acid 4 N | Mol Wt: 36.46 | 7647-01-0 | MFCD00011324 | 4 L
Aqua Solutions Hydrochloric Acid 0.1 Normal NIST Traceable (4L)
Hydrochloric Acid 0.1 Normal NIST Traceable (4L)
Cayman Chemical 12 0 N-BIotInyl Faty AcId 10mg
A biotinylated form of lauric acid; an intermediate in the synthesis of N-biotinylated phenylarsonous acids